Visie & Beleidsplein

Is dementia incidence declining?

trends in dementia incidence since 1990 in the Rotterdam Study

Schrijvers, E.M.C., Verhaaren, B.F.J., & Koudstaal, P. (2012). Is dementia incidence declining?: trends in dementia incidence since 1990 in the Rotterdam Study. Neurology 78 (pp. 1456-1463)

Objective: To investigate whether dementia incidence has changed over the last 2 decades. Results: In the 1990 subcohort (25,696 person-years), 286 persons developed dementia, and in the 2000 subcohort (8,384 person-years), 49 persons. Age-adjusted dementia incidence rates were consistently, yet nonsignificantly, lower in the 2000 subcohort in all strata, reaching borderline significance in the overall analysis (incidence rate ratio 0.75, 95% confidence interval [CI] 0.56-1.02). Mortality rates were also lower in the 2000 subcohort (rate ratio 0.63, 95% CI 0.52-0.77). The prevalence of hypertension and obesity significantly increased between 1990 and 2000. This was paralleled by a strong increase in use of antithrombotics and lipid-lowering drugs. Participants in 2005-2006 had larger total brain volumes (p < 0.001) and less cerebral small vessel disease (although nonsignificant in men) than participants in 1995-1996. Conclusions: Although the differences in dementia incidence were nonsignificant, our study suggests that dementia incidence has decreased between 1990 and 2005.

Uitgever(s):

Download(s)

ARTIKEL NIET EXTERN VERSPREIDEN IVM AUTEURSRECHTEN - Is dementia incidence declining? : trends in dementia incidence since 1990 in the Rotterdam Study

Download PDF

Auteur(s)

Klik op de auteur meer artikelen te zoeken van deze auteur.

Elisabeth Schrijvers
B. Verhaaren
Peter Koudstaal

Tags van dit artikel

Klik op de tag meer artikelen te zoeken met deze tag.

dementie
statistische gegevens