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The relationship between step count and all-cause mortality and cardiovascular events

a dose–response meta-analysis

Sheng, M., Yang, J., Bao, M., Chen, T., Cai, R., Zhang, N., ... Chao, J. (2021). The relationship between step count and all-cause mortality and cardiovascular events: a dose–response meta-analysis. Journal of Sport and Health Science

Highlights

  • Higher step count is inversely associated with the risk of premature death and cardiovascular events.
  • 8959 steps/day (Q3) measured by accelerometers had a 40.36% lower risk of all-cause mortality than 4183 steps/day (Q1).
  • 9500 steps/day (Q3) measured by accelerometers had a 35.05% lower risk of cardiovascular events than 3500 steps/day(Q1).
  • These associations were in nonlinear dose–response patterns.

Background: A goal of 10,000 steps per day is widely advocated, but there is little evidence to support that goal. Our purpose was to examine the dose–response relationships between step count and mortality and cardiovascular disease risk.

Methods: Cochrane Central Register of Controlled Trials, EMBASE, OVID, PubMed, Scopus, and Web of Science databases were systematically searched for studies published before July 09, 2021, that evaluated the association between daily steps and at least 1 outcome.

Results: Sixteen publications (12 related to all-cause mortality, 5 related to cardiovascular disease, 1 article contained 2 outcomes: both all-cause death and cardiovascular events.) were eligible for inclusion in the meta-analysis. There was evidence of a nonlinear dose–response relationship between step count and risk of all-cause mortality or cardiovascular disease (p?=?0.002 and p?=?0.014 for nonlinearity, respectively). When we restricted the analyses to accelerometer-based studies, the third quartile had a 40.36% lower risk of all-cause mortality and a 35.05% lower risk of cardiovascular event than the first quartile (all-cause mortality: Q1?=?4183 steps/day, Q3?=?8959 steps/day; cardiovascular event: Q1?=?3500 steps/day, Q3?=?9500 steps/day; respectively).

Conclusions: Our meta-analysis suggests inverse associations between higher step count and risk of premature death and cardiovascular events in middle-aged and older adults, with nonlinear dose–response patterns.

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Mingxin Sheng
Junyue Yang
Min Bao
Tianzhi Chen
Ruixue Cai
Na Zhang
Hongling Chen
Minqi Liu
Xueyu Wu
Bowen Zhang
Yiting Liu
Jianqian Chao

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gezonde leefstijl
hart- en vaatziekten
overlijden
preventie
stappenteller
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