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Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women

the European Prospective Investigation into Cancer and Nutrition Study (EPIC)

Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall and abdominal obesity remains unclear. Objective: We examined whether overall and abdominal adiposity modified the association between PA and all-cause mortality and estimated the population attributable fraction (PAF) and the years of life gained for these exposures. Results: Significant interactions were observed, so HRs were estimated within BMI and WC (Height, weight, and waist circumference) strata. The hazards of all-cause mortality were reduced by 16-30% in moderately inactive individuals compared with those categorized as inactive in different strata of BMI and WC. Avoiding all inactivity would theoretically reduce all-cause mortality by 7.35%. Corresponding estimates for avoiding obesity were 3.66%. The estimates for avoiding high WC were similar to those for physical inactivity. Conclusion: The greatest reductions in mortality risk were observed between the 2 lowest activity groups across levels of general and abdominal adiposity, which suggests that efforts to encourage even small increases in activity in inactive individuals may be beneficial to public health.

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Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women : the European Prospective Investigation into Cancer and Nutrition Study (EPIC)

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Ulf Ekelund
Heather Ward
Teresa Norat
Jian'an Luan
Anne May
Elisabete Weiderpass
Stephen Sharp
Kim Overvad
Jane Nautrup Østergaard
Anne Tjønneland
Nina Føns Johnsen
Sylvie Mesrine
Agnès Fournier
Guy Fagherazzi
Antonia Trichopoulou
Pagona Lagiou
Dimitrios Trichopoulos
Kuanrong Li
Rudolf Kaaks
Pietro Ferrari
Idlir Licaj
Mazda Jenab
Manuela Bergmann
Heiner Boeing
Domenico Palli
Sabina Sieri
Salvatore Panico
Rosario Tumino
Paolo Vineis
Petra Peeters
Evelyn Monnikhof
Bas Bueno-de-Mesquita
Ramón Quirós
Antonio Agudo
María-José Sánchez
José María Huerta
Eva Ardanaz
Larraitz Arriola
Elisabet Wirfält
Malin Sund
Mattias Johansson
Timothy Key
Ruth Travis
Kay-Tee Khaw
Søren Brage
Nicholas Wareham
Elio Riboli

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beweegstimulering
lichaamsbeweging
overgewicht
overlijden

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