« Terug naar overzicht

Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality

systematic review and harmonised meta-analysis

Objective: To examine the dose-response associations between accelerometer assessed total physical activity, different intensities of physical activity, and sedentary time and all cause mortality.

Results: 39 studies were retrieved for full text review; 10 were eligible for inclusion, three were excluded owing to harmonisation challenges (eg, wrist placement of the accelerometer), and one study did not participate. Two additional studies with unpublished mortality data were also included. Thus, individual level data from eight studies (n=36 383; mean age 62.6 years; 72.8% women), with median follow-up of 5.8 years (range 3.0-14.5 years) and 2149 (5.9%) deaths were analysed. Any physical activity, regardless of intensity, was associated with lower risk of mortality, with a non-linear dose-response. Hazards ratios for mortality were 1.00 (referent) in the first quarter (least active), 0.48 (95% confidence interval 0.43 to 0.54) in the second quarter, 0.34 (0.26 to 0.45) in the third quarter, and 0.27 (0.23 to 0.32) in the fourth quarter (most active). Corresponding hazards ratios for light physical activity were 1.00, 0.60 (0.54 to 0.68), 0.44 (0.38 to 0.51), and 0.38 (0.28 to 0.51), and for moderate-to-vigorous physical activity were 1.00, 0.64 (0.55 to 0.74), 0.55 (0.40 to 0.74), and 0.52 (0.43 to 0.61). For sedentary time, hazards ratios were 1.00 (referent; least sedentary), 1.28 (1.09 to 1.51), 1.71 (1.36 to 2.15), and 2.63 (1.94 to 3.56).

Conclusion: Higher levels of total physical activity, at any intensity, and less time spent sedentary, are associated with substantially reduced risk for premature mortality, with evidence of a non-linear dose-response pattern in middle aged and older adults.

Uitgever(s):

Download(s)

and all cause mortality : systematic review and harmonised meta-analysis

Download PDF

---

Auteur(s)

Klik op de auteur meer artikelen te zoeken van deze auteur.

Ulf Ekelund
Jakob Tarp
Jostein Steene-Johannessen
Bjørge Hansen
Barbara Jefferis
Morten Wang Fagerland
Peter Whincup
Keith Diaz
Steven Hooker
Ariel Chernofsky
Martin Larson
Nicole Spartano
Ramachandran Vasan
Ing-Mari Dohrn
Maria Hagströmer
Charlotte Edwardson
Thomas Yates
Eric Shiroma
Sigmund Anderssen
I-Min Lee

---

Tags van dit artikel

Klik op de tag meer artikelen te zoeken met deze tag.

activiteitenmeter
lichaamsbeweging
overlijden
reviews
sedentair gedrag
trainingsintensiteit

---